Current Concepts in ER Stress-Induced Apoptosis
نویسندگان
چکیده
منابع مشابه
Current Concepts in ER Stress-Induced Apoptosis
Tumour development and progression is associated with cancer cell stress, owing to the rapid proliferative rate of cancer cells. During these processes cancer cells encounter severe cytotoxic conditions such as hypoxia, nutrient deprivation, metabolic changes and acidosis. As a consequence cancer cells must possess high adaptive capabilities in order to contend with such stresses. One of the ad...
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Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of ischemic and neurodegenerative disorders. Treatment of human SH-SY5Y neuroblastoma cells with tunicamycin, an inhibitor of protein glycosylation, rapidly induced the expression of target genes of the unfolded protein response. However, prolonged treatment also triggered a delayed, caspase-dependent cell death. Microarr...
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Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved "core" functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than "private" ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA indu...
متن کامل( AICD ) potentiates ER stress mediated apoptosis
Altered processing of the Amyloid Precursor Protein (APP) plays a pivotal role in the pathogenesis of Alzheimer's disease. Recent research has revealed an interesting biological function for the APP intracellular domain (AICD), the short APP C-terminal region which generated by ␥-and/or ⑀-secretase cleavage. In a manner analogous to the Notch signalling pathway, AICD binds to several co-factors...
متن کاملER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.
Accumulation of unfolded proteins induces endoplasmic reticulum (ER) stress. Excessive and prolonged stresses lead cells to apoptosis. However, the precise molecular mechanisms of ER stress-induced apoptosis have not been fully elucidated. We investigated the involvement of the apoptosome in ER stress-induced cell death pathway using mouse embryonic fibroblasts (MEFs) and mice deficient for Apa...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2013
ISSN: 2157-2518
DOI: 10.4172/2157-2518.s6-002